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發(fā)表于 2015-06-17 08:59
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家蠶基因組生物學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室主任
西南大學(xué)教授、博士生導(dǎo)師
西南大學(xué)生物技術(shù)學(xué)院院長(zhǎng)
國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）首席科學(xué)家
“長(zhǎng)江學(xué)者”獎(jiǎng)勵(lì)計(jì)劃特聘教授
國(guó)家百千萬(wàn)人才
簡(jiǎn)歷：
1981－1985，西南農(nóng)業(yè)大學(xué)本科生。
1985－1996，四川省農(nóng)科院蠶研所工作。
1991－1996，西南農(nóng)業(yè)大學(xué)博士生。
1997－2001，日本九州大學(xué)博士后、特別研究員。
2000 - ，西南大學(xué)教授、博導(dǎo)
2002 - ，農(nóng)業(yè)部蠶桑功能基因組與生物技術(shù)重點(diǎn)開放實(shí)驗(yàn)室副主任
2005–2007，西南大學(xué)蠶學(xué)與生物技術(shù)學(xué)院院長(zhǎng)
2005- ，教育部家蠶基因組學(xué)重點(diǎn)實(shí)驗(yàn)室副主任
2006- ，西南大學(xué)蠶學(xué)與系統(tǒng)生物學(xué)研究所副所長(zhǎng)
2007- ，西南大學(xué)生物技術(shù)學(xué)院院長(zhǎng)
2011- ，家蠶基因組生物學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室主任
主要科研領(lǐng)域與方向:
家蠶分子生物學(xué)、基因組與功能基因組，利用轉(zhuǎn)基因等技術(shù)進(jìn)行家蠶品種改良和素材創(chuàng)新等。
科學(xué)成就：
一、完成中國(guó)家蠶基因組計(jì)劃
2004年繪制了6X家蠶全基因組框架圖，負(fù)責(zé)項(xiàng)目策劃、測(cè)序指揮到論文撰寫，以第一作者在Science上發(fā)表成果。2008年與日本合作，繪制了家蠶基因組9X精細(xì)圖譜，并作為客座編輯組織了Insect Biochem Mol Biol《家蠶基因組特別刊》，以第一作者發(fā)表了主題論文。2009年完成了40個(gè)蠶品系的基因組重測(cè)序和高精度遺傳變異圖譜繪制。發(fā)現(xiàn)1600萬(wàn)個(gè)SNP位點(diǎn)、31萬(wàn)個(gè)插入缺失突變和3.5萬(wàn)個(gè)基因組結(jié)構(gòu)變異，發(fā)現(xiàn)家蠶由中國(guó)野桑蠶而來(lái)的馴化為單一事件，并以第一作者在Science上發(fā)表成果。
二、建立家蠶功能基因組研究平臺(tái)技術(shù)
主持構(gòu)建了家蠶遺傳數(shù)據(jù)庫(kù)SilkDB，成為國(guó)際蠶學(xué)和昆蟲學(xué)領(lǐng)域基因組權(quán)威數(shù)據(jù)平臺(tái)；主持研制了世界首張家蠶全基因組Oligo芯片，完成了家蠶10萬(wàn)條EST測(cè)序和32個(gè)重要組織、器官的基因表達(dá)分析。主持建立了國(guó)際一流的基因定位克隆、RNAi、轉(zhuǎn)基因和基因定向敲除等平臺(tái)。整體水平居國(guó)際領(lǐng)先，部分成果已發(fā)表于PNAS、Genome Bio、Nucleic Acids Res和Transgenic Res等。
三、在重要基因鑒定和功能解析方面有眾多發(fā)現(xiàn)
提出了蠶絲蛋白合成、性別決定、免疫調(diào)控和發(fā)育與變態(tài)等為家蠶功能基因組研究中的首要目標(biāo)并得到國(guó)內(nèi)外同行認(rèn)可。圍繞該四大性狀，系統(tǒng)鑒定分析了主要性狀相關(guān)調(diào)控基因3000余個(gè)，重點(diǎn)克隆研究了50余個(gè)關(guān)鍵基因的功能，申請(qǐng)基因?qū)＠?6余項(xiàng)，在Nat Biotechnol、Plos One、Genomics、BMC Dev Biol、Dev Comp Immunol和Insect Biochem Mol Biol等雜志發(fā)表家蠶研究論文超過(guò)200篇，影響因子合計(jì)逾300分。
四、國(guó)際交流與人才培養(yǎng)
多次被相關(guān)國(guó)際學(xué)術(shù)會(huì)議選為執(zhí)行主席和特邀報(bào)告人，并在澳大利亞國(guó)立大學(xué)、墨爾本大學(xué)等四所知名大學(xué)講學(xué)。先后主持8個(gè)重要國(guó)際合作項(xiàng)目。被聘為教育部“長(zhǎng)江學(xué)者”和“長(zhǎng)江學(xué)者與創(chuàng)新團(tuán)隊(duì)發(fā)展計(jì)劃”創(chuàng)新團(tuán)隊(duì)帶頭人，973首席科學(xué)家，省部學(xué)科及學(xué)術(shù)技術(shù)帶頭人，主持973、863等項(xiàng)目30余個(gè)，獲“十一五”國(guó)家科技計(jì)劃執(zhí)行突出貢獻(xiàn)獎(jiǎng)。先后獲全國(guó)五一勞動(dòng)獎(jiǎng)?wù)�、光華工程科技獎(jiǎng)青年獎(jiǎng)、全國(guó)優(yōu)秀科技工作者、中國(guó)青年科技獎(jiǎng)、全國(guó)師德先進(jìn)個(gè)人、全國(guó)紡織行業(yè)年度創(chuàng)新人物、桑麻紡織科技大獎(jiǎng)、重慶杰出貢獻(xiàn)英模和重慶市優(yōu)秀共產(chǎn)黨員等榮譽(yù)和稱號(hào)。已培養(yǎng)畢業(yè)博士研究生17人、碩士研究生38人，指導(dǎo)留學(xué)生2人，他們中先后獲中國(guó)青少年科技創(chuàng)新獎(jiǎng)、全國(guó)“挑戰(zhàn)杯”一等獎(jiǎng)、澳大利亞化學(xué)感受科學(xué)大會(huì)“最佳學(xué)生獎(jiǎng)”等多項(xiàng)獎(jiǎng)勵(lì)。
代表性論文：
1: Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C, Pan G, Xu J, Liu C, Lin Y, Qian J, Hou Y, Wu Z, Li G, Pan M, Li C, Shen Y, Lan X, Yuan L, Li T, Xu H, Yang G, Wan Y, Zhu Y, Yu M, Shen W, Wu D, Xiang Z, Yu J, Wang J, Li R, Shi J, Li H, Li G, Su J, Wang X, Li G, Zhang Z, Wu Q, Li J, Zhang Q, Wei N, Xu J, Sun H, Dong L, Liu D, Zhao S, Zhao X, Meng Q, Lan F, Huang X, Li Y, Fang L, Li C, Li D, Sun Y, Zhang Z, Yang Z, Huang Y, Xi Y, Qi Q, He D, Huang H, Zhang X, Wang Z, Li W, Cao Y, Yu Y, Yu H, Li J, Ye J, Chen H, Zhou Y, Liu B, Wang J, Ye J, Ji H, Li S, Ni P, Zhang J, Zhang Y, Zheng H, Mao B, Wang W, Ye C, Li S, Wang J, Wong GK, Yang H; Biology Analysis Group. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004, 306(5703):1937-40.
2: Xia Q, Guo Y, Zhang Z, Li D, Xuan Z, Li Z, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen Y, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang Z*, Wang J*. Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science. 2009, 326(5951):433-6.
3: Xia Q, Cheng D, Duan J, Wang G, Cheng T, Zha X, Liu C, Zhao P, Dai F, Zhang Z, He N, Zhang L, Xiang Z. Microarray-based gene expression profiles in multiple tissues of the domesticated silkworm, Bombyx mori. Genome Biol. 2007,8(8):R162.
4: Xia QY, Fujii H, Kusakabe T, Banno Y. Identification of three annexin IX isoforms generated by alternative splicing of the carboxyl-terminal exon in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2001,32(1):9-14.
5: Liu C, Yamamoto K, Cheng TC, Kadono-Okuda K, Narukawa J, Liu SP, Han Y, Futahashi R, Kidokoro K, Noda H, Kobayashi I, Tamura T, Ohnuma A, Banno Y, Dai FY, Xiang ZH, Goldsmith MR, Mita K, Xia QY*. Repression of tyrosine hydroxylase is responsible for the sex-linked chocolate mutation of the silkworm, Bombyx mori. Proc Natl Acad Sci U S A. 2010, 107(29):12980-5.
6: Duan J, Li R, Cheng D, Fan W, Zha X, Cheng T, Wu Y, Wang J, Mita K, Xiang Z, Xia Q*. SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology. Nucleic Acids Res. 2010,38(Database issue) 453-6.
7: Zhao P, Dong Z, Duan J, Wang G, Wang L, Li Y, Xiang Z, Xia Q*. Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori. PLoS One. 2012;7(2):e31168.
8: Xie X, Cheng T, Wang G, Duan J, Niu W, Xia Q*. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in the silkworm, Bombyx mori. Mol Biol Rep. 2012 Feb 5.
9: Yang W, Cheng T, Ye M, Deng X, Yi H, Huang Y, Tan X, Han D, Wang B, Xiang Z, Cao Y*, Xia Q*. Functional divergence among silkworm antimicrobial peptide paralogs by the activities of recombinant proteins and the induced expression profiles. PLoS One. 2011,29;6(3):e18109.
10: Ma L, Xu H, Zhu J, Ma S, Liu Y, Jiang RJ, Xia Q*, Li S*. Ras1(CA) overexpression in the posterior silk gland improves silk yield. Cell Res. 2011, 21(6):934-43.
11: Wei L, Cheng D, Li D, Meng M, Peng L, Tang L, Pan M, Xiang Z, Xia Q*, Lu C*. Identification and characterization of Sox genes in the silkworm, Bombyx mori. Mol Biol Rep. 2011, 38(5):3573-84.
12: Zhao P, Wang GH, Dong ZM, Duan J, Xu PZ, Cheng TC, Xiang ZH, Xia QY*. Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori. BMC Genomics. 2010,11:405.
13: Xiang H, Zhu J, Chen Q, Dai F, Li X, Li M, Zhang H, Zhang G, Li D, Dong Y, Zhao L, Lin Y, Cheng D, Yu J, Sun J, Zhou X, Ma K, He Y, Zhao Y, Guo S, Ye M, Guo G, Li Y, Li R, Zhang X, Ma L, Kristiansen K, Guo Q, Jiang J, Beck S, Xia Q*, Wang W*, Wang J*. Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol. 2010, 28(5):516-20.
14: Li D, Guo Y, Shao H, Tellier LC, Wang J, Xiang Z, Xia Q*. Genetic diversity, molecular phylogeny and selection evidence of the silkworm mitochondria implicated by complete resequencing of 41 genomes. BMC Evol Biol. 2010, 10:81.
15: Liu S, Li D, Li Q, Zhao P, Xiang Z, Xia Q*. MicroRNAs of Bombyx mori identified by Solexa sequencing. BMC Genomics. 2010,11:148.
16: Liu S, Gao S, Zhang D, Yin J, Xiang Z, Xia Q*. MicroRNAs show diverse and dynamic expression patterns in multiple tissues of Bombyx mori. BMC Genomics. 2010,11:85.
17: Huang L, Cheng T, Xu P, Cheng D, Fang T, Xia Q*. A genome-wide survey for host response of silkworm, Bombyx mori during pathogen Bacillus bombyseptieus infection. PLoS One. 2009,4(12):e8098.
18: Gong DP, Zhang HJ, Zhao P, Xia QY*, Xiang ZH. The odorant binding protein gene family from the genome of silkworm, Bombyx mori. BMC Genomics. 2009,10:332.
19: Huang L, Cheng T, Xu P, Duan J, Fang T, Xia Q*. Immunoglobulin superfamily is conserved but evolved rapidly and is active in the silkworm, Bombyx mori. Insect Mol Biol. 2009,18(4):517-30.
20: Zhang Y*, Xia Q*, Xu J, Chen J, Nie Z, Wang D, Zhang W, Chen J, Zheng Q, Chen Q, Kong L, Ren X, Wang J, Lv Z, Yu W, Jiang C, Liu L, Sheng Q, Jin Y, Wu X. Aligning the proteome and genome of the silkworm, Bombyx mori. Funct Integr Genomics. 2009, 9(4):447-54.
21: Liu Z, Xia L, Wu Y, Xia Q, Chen J, Roux KH. Identification and
characterization of an arginine kinase as a major allergen from silkworm (Bombyx mori) larvae. Int Arch Allergy Immunol. 2009,150(1):8-14.
22: Couble P, Mita K, Xia Q. Editorial: Silkworm genome. Insect Biochem Mol Biol. 2008, 38(12):1035.
23: Zha X, Xia Q*, Duan J, Wang C, He N, Xiang Z. Dosage analysis of Z chromosome genes using microarray in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2009, 39(5-6):315-21.
24: Cheng D, Xia Q*, Duan J, Wei L, Huang C, Li Z, Wang G, Xiang Z. Nuclear receptors in Bombyx mori: insights into genomic structure and developmental expression. Insect Biochem Mol Biol. 2008, 38(12):1130-7.
25: Duan J, Xia Q*, Cheng D, Zha X, Zhao P, Xiang Z. Species-specific expansion of C2H2 zinc-finger genes and their expression profiles in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2008 ,38(12):1121-9.
26: Liu S, Xia Q*, Zhao P, Cheng T, Hong K, Xiang Z. Characterization and expression patterns of let-7 microRNA in the silkworm (Bombyx mori). BMC Dev Biol. 2007,7:88.
27: Zhao P, Xia Q*, Li J, Fujii H, Banno Y, Xiang Z. Purification, characterization and cloning of a chymotrypsin inhibitor (CI-9) from the hemolymph of the silkworm, Bombyx mori. Protein J. 2007, 26(5):349-57.
28: Cheng TC, Zhang YL, Liu C, Xu PZ, Gao ZH, Xia QY*, Xiang ZH. Identification and analysis of Toll-related genes in the domesticated silkworm, Bombyx mori. Dev Comp Immunol. 2008,32(5):464-75.
29: Hou Y, Xia Q*, Zhao P, Zou Y, Liu H, Guan J, Gong J, Xiang Z. Studies on middle and posterior silk glands of silkworm (Bombyx mori) using two-dimensional electrophoresis and mass spectrometry. Insect Biochem Mol Biol. 2007, 37(5):486-96.
30: Gong J, Hou Y, Zha XF, Lu C, Zhu Y, Xia QY*. Molecular cloning and characterization of Bombyx mori sterol carrier protein x/sterol carrier protein 2 (SCPx/SCP2) gene. DNA Seq. 2006, 17(5):326-33.
31: Gong DP, Zhang HJ, Zhao P, Lin Y, Xia QY*, Xiang ZH. Identification and expression pattern of the chemosensory protein gene family in the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2007, 37(3):266-77.
32: Xu HF, Xia QY*, Liu C, Cheng TC, Zhao P, Duan J, Zha XF, Liu SP. Identification and characterization of piggyBac-like elements in the genome of domesticated silkworm, Bombyx mori. Mol Genet Genomics. 2006, 276(1):31-40.
33: Cheng T, Zhao P, Liu C, Xu P, Gao Z, Xia Q*, Xiang Z. Structures, regulatory regions, and inductive expression patterns of antimicrobial peptide genes in the silkworm Bombyx mori. Genomics. 2006, 87(3):356-65.
34: Cheng DJ, Xia QY*, Zhao P, Wang ZL, Xu HF, Li GR, Lu C, Xiang ZH. EST-based profiling and comparison of gene expression in the silkworm fat body during metamorphosis. Arch Insect Biochem Physiol. 2006, 61(1):10-23.
35: Li B, Xia Q*, Lu C*, Zhou Z, Xiang Z. Analysis of cytochrome P450 genes in silkworm genome (Bombyx mori). Sci China C Life Sci. 2005, 48(4):414-8.
36: Zha XF, Xia QY*, Zhao P, Li J, Duan J, Wang ZL, Qian JF, Xiang ZH. Detection and analysis of alternative splicing in the silkworm by aligning expressed sequence tags with the genomic sequence. Insect Mol Biol. 2005, 14(2):113-9.
37: Wang J, Xia Q, He X, Dai M, Ruan J, Chen J, Yu G, Yuan H, Hu Y, Li R, Feng T, Ye C, Lu C, Wang J, Li S, Wong GK, Yang H, Wang J, Xiang Z, Zhou Z, Yu J. SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res. 2005, 1;33(Database issue)399-402.
38: Cheng TC, Xia QY*, Liu C, Zhao P, Zha XF, Xu HF, Xiang ZH. [Three Bombyx mori genes, chi, gluE and fruA, encode proteins homologous to microorganism and primary analysis of horizontal gene transfer]. Yi Chuan Xue Bao. 2004, 31(10):1082-8.
39: Cheng TC, Xia QY*, Qian JF, Liu C, Lin Y, Zha XF, Xiang ZH. Mining single nucleotide polymorphisms from EST data of silkworm, Bombyx mori, inbred strain Dazao. Insect Biochem Mol Biol. 2004, 34(6):523-30.
出版專著：
夏慶友, 向仲懷 主編. 《家蠶基因組計(jì)劃2000-2007》,西南師范大學(xué)出版社, 2008.6
夏慶友，向仲懷 主編. 《家蠶基因組計(jì)劃2008-2009》（上、下冊(cè)），西南師范大學(xué)出版社，2010.12
聯(lián)系地址： 400716，西南大學(xué) 家蠶基因組生物學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室
電 話： 023-68250099
傳 真： 023-62251128
E-mail ： xiaqy@swu.edu.cn
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