中國藥科大學(xué)

陳西敬教授，博士生導(dǎo)師

聯(lián)系方式:地址:南京市中央路童家巷24號(hào)（210009）

手機(jī):13605160357,電話:025-83271286(玄武門校區(qū)),025-86185379(江寧校區(qū))

E-mail:83271286@163.com

專業(yè)研究方向：藥物代謝動(dòng)力學(xué)

一、主要學(xué)習(xí)和工作經(jīng)歷

1992年中國藥科大學(xué)藥物代謝動(dòng)力學(xué)專業(yè)碩士畢業(yè)后留校任教，歷任助教，講師和副教授，2001年獲藥動(dòng)學(xué)與生物藥劑學(xué)專業(yè)博士學(xué)位，2002年至2003年作為訪問學(xué)者于日本近畿大學(xué)生物藥劑學(xué)實(shí)驗(yàn)室從事藥代動(dòng)力學(xué)領(lǐng)域的合作研究，2007年被評(píng)為教授，2008年晉升為博士生導(dǎo)師。

二、主要科研工作簡介

現(xiàn)任中國藥科大學(xué)中國藥科大學(xué)藥物代謝與動(dòng)力學(xué)研究中心教授，藥物代謝重點(diǎn)實(shí)驗(yàn)室生物大分子室負(fù)責(zé)人，江蘇省青藍(lán)工程優(yōu)秀青年骨干教師，國家SFDA和江蘇省新藥審評(píng)專家，科技部“863”計(jì)劃生物醫(yī)藥領(lǐng)域?qū)徳u(píng)專家，教育部基金審評(píng)專家，《中國實(shí)用藥學(xué)》副主編并擔(dān)任《Journal of Pharmacy and Pharmacology》、《Acta Pharmacologica Sinica》、《Journal of Pharmaceutical and Biomedical Analysis》等國內(nèi)外藥學(xué)期刊審稿人。主持國家863項(xiàng)目1項(xiàng)，主持并完成國家自然科學(xué)基金項(xiàng)目1項(xiàng)，作為主要完成者參與了科技部重大專項(xiàng)和國家自然科學(xué)基金重點(diǎn)項(xiàng)目等國家級(jí)項(xiàng)目多項(xiàng)。承擔(dān)并完成企業(yè)委托研究項(xiàng)目近百項(xiàng)，其中國家一類新藥的非臨床藥代動(dòng)力學(xué)研究項(xiàng)目8項(xiàng)，二類新藥的臨床藥代動(dòng)力學(xué)研究項(xiàng)目2項(xiàng),近五年科研經(jīng)費(fèi)共四百多萬元。獲得國家科技進(jìn)步二等獎(jiǎng)1項(xiàng)，江蘇省科技進(jìn)步一等獎(jiǎng)1項(xiàng)，獲得省教學(xué)成果二等獎(jiǎng)和優(yōu)秀教材獎(jiǎng)各1項(xiàng)、獲國家發(fā)明專利1項(xiàng)。在國內(nèi)外學(xué)術(shù)刊物上發(fā)表學(xué)術(shù)論文100多篇，其中SCI收錄40余篇，主編《藥物代謝動(dòng)力學(xué)研究進(jìn)展》專著1部。已培養(yǎng)博士和碩士研究生40多名,他們中部分到國外或國內(nèi)大學(xué)繼續(xù)深造，其余已成為科研單位或企業(yè)的技術(shù)骨干。

三、研究領(lǐng)域

1、藥物代謝動(dòng)力學(xué)研究

研究方向包括創(chuàng)新藥物的吸收、分布、代謝、排泄及其機(jī)制研究，新藥的I期臨床藥代動(dòng)力學(xué)研究，藥物轉(zhuǎn)運(yùn)體和代謝酶基因多態(tài)性對(duì)藥物動(dòng)力學(xué)影響，轉(zhuǎn)運(yùn)體和酶介導(dǎo)的藥物相互作用研究等。其中對(duì)藥物轉(zhuǎn)運(yùn)體的研究是本實(shí)驗(yàn)室的主要研究方向之一。

藥物轉(zhuǎn)運(yùn)體(DrugTransporters)是具有轉(zhuǎn)運(yùn)內(nèi)源性或外源性化合物透過細(xì)胞膜功能的一類特殊蛋白質(zhì)，近年來國際藥學(xué)界對(duì)該領(lǐng)域的研究方興未艾。大量的研究成果表明，藥物轉(zhuǎn)運(yùn)體在藥物吸收，分布和排泄過程中發(fā)揮著重要的作用。本實(shí)驗(yàn)室利用動(dòng)物在體、離體和細(xì)胞轉(zhuǎn)染等技術(shù)對(duì)藥物的體內(nèi)轉(zhuǎn)運(yùn)機(jī)制進(jìn)行研究，力爭建成一個(gè)藥物研究的新平臺(tái)和藥動(dòng)學(xué)高級(jí)專門人才培養(yǎng)的基地。

2、生物大分子藥物的藥動(dòng)學(xué)與生物藥劑學(xué)研究

隨著生物醫(yī)學(xué)以及生物技術(shù)的發(fā)展，多肽與蛋白質(zhì)類藥物作為藥用生物活性大分子物質(zhì)正在成為一類很重要的治療藥物。已有越來越多的多肽和蛋白類藥物用于臨床治療。研究顯示，90%以上的這類藥物因口服易被破壞，目前只能采用注射給藥。為了避免頻繁注射給病人造成的痛苦，其非注射途徑給藥已成為國際藥學(xué)界的研究熱點(diǎn)之一。本課題組在江蘇省“新藥創(chuàng)制基金”和國家“863”項(xiàng)目的支持下，對(duì)包括肺吸入粉霧劑和結(jié)腸定位給藥在內(nèi)的多種給藥途徑進(jìn)行了研究，創(chuàng)建了藥劑學(xué)、藥動(dòng)學(xué)、藥效學(xué)和毒理學(xué)研究的相關(guān)技術(shù)平臺(tái)。

四、專著

陳西敬主編.《藥物代謝動(dòng)力學(xué)研究進(jìn)展》.化學(xué)工業(yè)出版社，2008.6.北京.

五、近年發(fā)表的部分論文

1.Yang S, Talbi A, Wang X, Song H, Chen X*.Pharmacokinetics study of calf thymus DNA in rats and beagle dogs with 3H-labeling and tracing method.J Pharm Biomed Anal. 2014;88(1):60-65.

2.Qiu Z, Li N, Song L, Lu Y, Jing J, Parekha HS, Gao W, Tian F, Wang X, Ren S, Chen X*. Contributions of Intestine and Plasma to the Presystemic Bioconversion of Vicagrel, an Acetate of Clopidogrel.. Pharm Res. 2014 Jan;31(1):238-51   

3.Zhao D, Zhang Y, Wang Y, Xu C, Dong C, Li C, Ren S, Zhang W, Lu Y, Dai Y, Chen X*.  Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method. J Pharm Biomed Anal,2014 Jan;88:331-6 

4.Li N, Qiu Z, Wang X, Li T, Ji H, Zhang Y, Lu Y, Zhao D, Chen X*. Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor. Xenobiotica. 2014 Jan;44(1):59-69.

5.Yang SY, Zheng Y, Chen JY, Zhang QY, Zhao D, Han DE, Chen XJ*. Comprehensive study of cationic liposomes composed of DC-Chol and cholesterol with different mole ratios for gene  transfection. Colloids Surf B Biointerfaces. 2013,101(1):6-13.

6.Qiu Z, Li N, Wang X, Tian F, Liu Q, Song L, Fan Z, Lu Y, Chen X*. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs. J Pharm Sci. 2013, 102(2):741-9.

7.Zhang Y, Zhao D, Xu J, Xu C, Dong C, Liu Q, Deng S, Zhao J, Zhang W, Chen X*. Effects of Dietary Factors on the Pharmacokinetics of (58)Fe-labeled Hemin After Oral Administration in Normal Rats and the Iron-deficient Rats. Biol Trace Elem Res. 2013,153(1-3):243-50.

8.Wang X, Song L, Li N, Qiu Z, Zhou S, Li C, Zhao J, Song H, Chen X*. Pharmacokinetics and biodistribution study of Paclitaxel liposome in sprague-dawley rats and beagle dogs by liquid chromatography-tandem mass spectrometry. Drug Res (Stuttg). 2013,63(11):603-6.

9.Zhao D, Zhang Y, Xu C, Dong C, Lin H, Zhang L, Li C, Ren S, Wang X, Yang S, Han D, Chen X. Pharmacokinetics, tissue distribution, and plasma protein binding study of platinum originating from dicycloplatin, a novel antitumor supramolecule, in rats and dogs by ICP-MS.  Biol Trace Elem Res. 2012 Aug;148(2):203-8   

10.Zhao D, Gao ZD, Han DE, Li N, Zhang YJ, Lu Y, Li TT, Chen XJ. Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx.  Phytother Res. (2012) Phytother Res. 2012 Jan;26(1):118-21

11.Shuoye Yang, Qiuyang Zhang, Jiayin Chen, Deen Han, Di Zhao, Xijing Chen. Pharmacokinetics and disposition study of calf thymus DNA in rats by applying 3H-labelling method.  Journal of Pharmaceutical and Biomedical Analysis. 2012, 64-65: 35-39. 

12.Yang S, Chen J, Zhao D, Han D, Chen X. Comparative study on preparative methods of DC-Chol/DOPE liposomes and formulation optimization by determinating encapsulation efficiency.  Int J Pharm. 2012 Sep 15;434 (1-2) :155-60 

13.Han DE, Zheng Y, Chen X, He J, Zhao D, Yang S, Zhang C, Yang Z. Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Salvianolic acid A.  Drug Metab Pharmacokinet. 2012 Dec 25;27(6):579-85.

14.Zhang L, Li N, Lai Y, Zhang Y, Chen X, Chen L, Ji H, Li C. Pharmacokinetic, distribution, metabolism, and excretion of (Z)-2-amino-1,5 -dihydro-1-methyl-5- [4-(mesyl)benzylidene]-4H- imidazol-4-one mesilate (ZLJ-601) in Sprague-Dawley rats.  Phytother Res. 2012 Jan;26(1):118-21 

15.Fang F, Lu Y, Liang Y, Zhu J, He J, Zheng J, Li N, Tang Y, Zhu J, Chen X. Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies.  Pharmazie. 2012 Aug;67(8):706-11. 

16.Zheng J, Zheng Y, Chen J, Fang F, He J, Li N, Tang Y, Zhu J, Chen X. Enhanced pulmonary absorption of recombinant human insulin by pulmonary surfactant and phospholipid hexadecanol tyloxapol through Calu-3 monolayers. Pharmazie. 2012 May;67(5):448-51.

17.Bing Yang, Yang Lu, Jianheng Zheng, Jing Zhu, Jiake He, Di Zhao, Pengfei Song and Xijing Chen. Pharmacokinetics of the prodrug thiamphenicol glycinate and its active parent compound thiamphenicol in beagle dogs following intravenous administration. Xenobiotica. 2011, 41(3): 226-31   

18.Jiake He, Zhixia Qiu, Ning Li, Yang Yu, Yang Lu, Deen Han, Tingting Li, Di Zhao, Wei Sun, Fang Fang, Jianheng Zheng, Hongwei Fan and Xijing Chen. Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. European Journal of Clinical Pharmacology. 2011, 67(7): 701-707 

19.Tingting Li, Yi Zheng, Feifei Fu, Hui Ji, Xijing Chen, Ying Zhao, Di Zhao, Ning Li, Lingli Zhang. Assessment of UDP-glucuronosyltransferase catalyzed formation of picroside II glucuronide in microsomes of different species and recombinant UGTs. Xenobiotica. 2011, 47:530-537        

20.Tingting Li, Qiaoling Yu, Deen Han, Ying Zhao, Di Zhao, Hui Ji, Xijing Chen，Ning Li, Zhixia Qiu, Yi Zheng. Structure elucidation of metabolites of picroside II in rat bile by LC-ESI-IT-MS. Chromatographia. 2011, 73:1111–1120  

21.Ning Li, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Zhixia Qiu, Di Zhao and Xijing Chen. Identification of circulatory and excretory metabolites of a novel nitric oxide-donor ZJM-289 in rat plasma, bile, urine, and feces by liquid chromatography-tandem mass spectrometry. Xenobiotica. 2011, 41(9):805-817     

22.Tingting Li, Ning Li, Qinglong Guo, Hui Ji, Di Zhao, Shan Xie, Xiaonan Li, Zhixia Qiu, Deen Han, Xijing Chen, Qidong You. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. European Journal of Drug Metabolism and Pharmacokinetics. 2011,36(4):249-56 

23.Di Zhao, Deen Han, Ning Li, Yang Lu, Tingting Li, Shuoye Yang, Jiake He, and Xijing Chen. Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. European Journal of Mass Spectrometry. 2011, 17(4):395-403