中國(guó)藥科大學(xué)

余伯陽，男，1959年3月生，教授、博士生導(dǎo)師。現(xiàn)任中國(guó)藥科大學(xué)研究生院常務(wù)副院長(zhǎng)；江蘇省中西醫(yī)結(jié)合一級(jí)學(xué)科重點(diǎn)學(xué)科學(xué)科帶頭人，江蘇省中藥評(píng)價(jià)與轉(zhuǎn)化重點(diǎn)實(shí)驗(yàn)室主任。全國(guó)首批新世紀(jì)“百千萬人才工程”國(guó)家級(jí)人選，享受國(guó)務(wù)院頒發(fā)的政府特殊津貼的專家，江蘇省跨世紀(jì)學(xué)術(shù)帶頭人，江蘇省有突出貢獻(xiàn)的中青年專家，江蘇省"333人才工程"（第二層次）人選，霍英東教育基金會(huì)第五屆高等院校青年教師獎(jiǎng)（研究類）獲得者，教育部高校優(yōu)秀骨干教師。兼任國(guó)家藥典委員會(huì)委員，國(guó)務(wù)院學(xué)位委員會(huì)學(xué)科評(píng)議組成員，全國(guó)藥學(xué)專業(yè)學(xué)位研究生教育指導(dǎo)委員會(huì)秘書長(zhǎng)，國(guó)家新藥審評(píng)專家，國(guó)家藥品價(jià)格評(píng)審專家，江蘇省政協(xié)常委等職務(wù)。

1989年畢業(yè)于中國(guó)藥科大學(xué)生藥學(xué)專業(yè)獲理學(xué)博士學(xué)位，導(dǎo)師為徐國(guó)均院士。1988年在日本昭和大學(xué)藥學(xué)部任客座研究員，1995年在美國(guó)伊利諾大學(xué)芝加哥分校藥學(xué)院從事博士后研究工作，1996年至1997年在美國(guó)依阿華大學(xué)藥學(xué)院任訪問教授。

研究方向與研究興趣：

1、中藥及復(fù)方藥效物質(zhì)基礎(chǔ)及作用機(jī)理研究（中西醫(yī)結(jié)合基礎(chǔ)（藥學(xué)））：利用化學(xué)與生物學(xué)相結(jié)合的方式，探索構(gòu)建物質(zhì)基礎(chǔ)與作用機(jī)制綜合分析研究體系用于中藥復(fù)方的評(píng)價(jià)研究。建立了整合指紋圖譜等分析技術(shù)，開展多組分協(xié)同作用、毒效相關(guān)分析、體內(nèi)外效應(yīng)物質(zhì)相關(guān)分析等研究；經(jīng)典復(fù)方的組方原理與組方優(yōu)化研究；源于療效確切的著名中成藥的組方優(yōu)化與二次開發(fā)研究

主要研究成果：

先后承擔(dān)國(guó)家863重大新藥創(chuàng)制項(xiàng)目、國(guó)家自然科學(xué)基金重大專項(xiàng)、國(guó)家科技支撐計(jì)劃等研究項(xiàng)目30多項(xiàng)；研究成果曾獲國(guó)家科技進(jìn)步一等、二等、三等獎(jiǎng)各1項(xiàng)，教育部高等學(xué)�？茖W(xué)研究?jī)?yōu)秀成果獎(jiǎng)二等獎(jiǎng)（自然科學(xué)類）1項(xiàng)，省部級(jí)科技進(jìn)步一等獎(jiǎng)3項(xiàng)、二等獎(jiǎng)3項(xiàng)。近年來，申請(qǐng)發(fā)明專利30多項(xiàng)，其中授權(quán)10多項(xiàng)，發(fā)表論文200多篇，其中SCI收錄100多篇。

聯(lián)系方式：

地址：南京市江寧大學(xué)城龍眠大道639號(hào)，中國(guó)藥科大學(xué)研究生院
郵編：211198
電話：025-86185157-8001；02586185287
郵箱：boyangyucpu@163.com

近五年來發(fā)表的代表性學(xué)術(shù)論文：
1.Identification and Determination of the Major Triterpenes in RhizomaAlismatis by HPLC-Evaporative Light Scattering Detection and HPLC/Electrospray Ionization-MSn [J] Journal of AOAC International. 2013, 96(2): 260-264.
2.Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation [J]. Journal of medicinal food. 2013, 16(4): 280-287.
3.A facile drug delivery system preparation through the interaction between drug and iron ion of transferring [J]. Journal of Nanoparticle Research. 2013, 15(9): 1-12.
4.Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. [J] International Immunopharmacology, 2013, 15: 240-245.
5.Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San. Pharmaceutical Biology, 2013, 51(10): 1219-1227.
6.Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke. European Journal of Pharmacology, 2013, 714: 303-311.
7.Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. Int Immunopharmacol. 2012, 12(1): 88-92.
8.Regio- and enantio- selective glycosylation of tetrahydroprotoberberines by Gliocladium deliquescens NRRL1086 resulting in unique alkaloidal glycosides. Appl Microbiol Biot, 2012, 93: 2357–2364.
9.Antioxidant anthocyanins screening through spectrum–effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem, 2012, 132: 759–765.
10.Efficient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase. Bioorg Med Chem Lett.2012, 22(9): 3100-3103.
11.Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int, 2011, 58(1): 119-125.
12.Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol, 2011, 49(9): 2243-2251.
13.New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation. Tetrahedron, 2011, 67(23): 4206-4211.
14.On-line high-performance liquid chromatography–diode detection–electrospray ionization–mass spectrometry–chemiluminescence assay of radical scavengers in Epimedium. J Chromatogr A, 2011, 121(9): 1227-1235.
15.Two new benzofuran derivatives with anti-inflammatory activity from Liriope spicata var. prolifera. Fitoterapia, 2011, 82(2): 190–192.
16.Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS. J Pharmaceut Biomed,2011,54 (5): 1110–1127.
17.Ruscogenin Mainly Inhibits Nuclear Factor-κB but Not Akt and Mitogen-Activated Protein Kinase Signaling Pathways in Human Umbilical Vein Endothelial Cells. J Pharmacol Sci, 2010,113(4): 409 – 413.
18.A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro. Int J Pharmaceut, 2010, 386(12): 131–137.
19.Effects of Storage Condition Factors on Fungal Invasion of Radix Ophiopogonis. J Agric Food Chem, 2010, 58(9): 5432-5437.
20.Homoisoflavonoids from the Fibrous Roots of Polygonatum odoratum with Glucose Uptake-Stimulatory Activity in 3T3-L1 Adipocytes. J Nat Prod, 2010, 73(4): 548–552.
21.One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorg Med Chem Lett, 2010, 20(14): 4015-4017.
22.Quality and antioxidant activity detection of Crataegus leaves using on-line high-performance liquid chromatography with diode detector coupled to chemiluminescence detection. Food Chem, 2010, 120(3): 929-933.
23.Microbial conversion of ruscogenin by Gliocladium deliquescens NRRL1086: glycosylation at C-1. Appl Microbiol Biot, 2010, 86(2): 491-497.
24.Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens. Planta Med, 2010, 76(16): 1892–1896.
25.Biotransformation of Bioactive Natural Products for Pharmaceutical Lead Compounds. Curr Org Chem, 2010, 14(14): 1400-1406.
26.Quality control of flavonoids in Ginkgo biloba leaves by high-performance liquid chromatography with diode detection and on-line radical scavenging activity detection. J Chrom. A, 2009,1216: 2204–2210
27.The antioxidant-activity-integrated fingerprint: An advantageous tool for the evaluation of quality of herbal medicines. J Chromatogr A. 2008, 1208(1-2):76-82
28.Evaluation of the analgesic and anti-inflammatory activities of Liu-Shen-Wan and its individual fractions in mice. J Ethnopharmacol., 2007,117:108-114
29.Determination of   glycyrrhizin in Chinese prescriptions and biological samples by enzyme-linked immunosorbent assay. Analytica Chimica Acta 2006; 564（2）：173-178
30.Novel biotransformation of pentacyclic triterpenoid acids by Nocardia sp. NRRL 5646. Tetrahedron Letter,2005,46,2337-2340