湖南師范大學(xué)

湖南師范大學(xué)生命科學(xué)學(xué)院動(dòng)物學(xué)研究生導(dǎo)師何善平介紹如下：

姓         名：何善平

職稱職務(wù)：特聘教授、博士生導(dǎo)師、國家青年****入選者        

專    業(yè)：生理學(xué)

研究領(lǐng)域：動(dòng)物分子營養(yǎng)與免疫

聯(lián)系電話：0731-88872199/18670326886

電子郵箱：hesp@hunnu.edu.cn

通訊地址：湖南省長沙市麓山路36號(hào)湖南師范大學(xué)生命科學(xué)學(xué)院3號(hào)樓A224，郵編 410081

個(gè)人簡介

北京大學(xué)理學(xué)博士，湖南師范大學(xué)“瀟湘學(xué)者”特聘教授、博士生導(dǎo)師，國家青年****和湖南省百人計(jì)劃（青年）入選者，第十二屆湖南省政協(xié)委員。2002年獲華中農(nóng)業(yè)大學(xué)農(nóng)學(xué)學(xué)士學(xué)位（動(dòng)物醫(yī)學(xué)專業(yè)），2011年獲北京大學(xué)理學(xué)博士學(xué)位（生物技術(shù)專業(yè)）；2011年至2016年，在美國南加州大學(xué)Keck醫(yī)學(xué)院分子微生物學(xué)與免疫學(xué)系從事博士后研究，研究腫瘤病毒調(diào)控天然免疫的分子機(jī)制。2016年作為海外高層次人才引進(jìn)，加入印遇龍?jiān)菏恐鞒值膭?dòng)物營養(yǎng)與人體健康實(shí)驗(yàn)室，從事動(dòng)物營養(yǎng)與免疫方面的研究。近年來，在Molecular Cell、PLoS Pathogens、Nucleic Acids Research等國際權(quán)威期刊發(fā)表高水平SCI論文10余篇，多次參加國際學(xué)術(shù)會(huì)議并做大會(huì)報(bào)告，參與翻譯出版權(quán)威教材1部，獲中國發(fā)明專利3項(xiàng)。目前主持國家青年****項(xiàng)目、湖南省百人計(jì)劃項(xiàng)目、湖南省科技創(chuàng)新平臺(tái)與人才計(jì)劃（人才類）、瀟湘學(xué)者特聘教授科研項(xiàng)目等4項(xiàng)人才計(jì)劃項(xiàng)目。承擔(dān)本科生《人體及動(dòng)物生理實(shí)驗(yàn)》教學(xué)工作，指導(dǎo)本科生的國家級(jí)大學(xué)生創(chuàng)新性實(shí)驗(yàn)。 

研究興趣

(1) 營養(yǎng)物質(zhì)調(diào)控腸道天然免疫的分子機(jī)制

(2) 氨基酸感知、抗病毒天然免疫的翻譯后修飾調(diào)控

代表性論文

(1) He S., Zhao J., Song S., He X., Minassian A., Zhou Y., Zhang J., Brulois K., Wang Y., Cabo J., Zandi E., Liang C., Jung J., Zhang X., Feng P. (2015) Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Molecular Cell 58, 134-146. (IF, 14.018) (在當(dāng)期Molecular Cell作為研究亮點(diǎn)獲得專評(píng)；Science Daily報(bào)道)

(2) Zhang J., He S., Wang Y., Brulois K., Lan K., Jung J., Feng P. (2015) Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase. PLoS Pathogens 11(3): e1004768. doi: 10.1371/journal.ppat.1004768. (IF, 8.057)

(3) Minassian A.#, Zhang J.#, He S., Zhao J., Zandi E., Saito T., Liang C., Feng P. An internally translated MAVS variant exposes its amino-terminal TRAF-binding motifs to deregulate interferon induction. PLoS Pathogens 11(7): e1005060. doi: 10.1371/journal.ppat.1005060. (#co-first author) (IF, 8.057)

(4) Zhao J., He S., Minassian A., Li J., Feng P. Recent advances on viral manipulation of NF-kappaB signaling pathway. Current Opinion in Virology 15, 103-111 (IF, 6.298)

(5) Zhang X., Wu Q., Cui S., Ren J., Qian W., Yang Y., He S., Chu J., Sun X., Yan C., Yu X., An C. (2015) Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Journal of Experimental Botany 66, 2709-2721. (IF, 5.794)

(6) Zhang X., Wu Q., Ren J., Qian W., He S., Huang K., Yu X., Gao Y., Huang P., An C. (2012) Two Novel RING-type Ubiquitin Ligases, RGLG3 and RGLG4, Are Essential for Jasmonate-mediated Responses in Arabidopsis. Plant Physiology 160, 808-822. (IF, 7.394)

(7) He S., Tan G., Liu Q., Huang K., Ren J., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-Interacting Protein GILP Is a LITAF Domain Protein That Negatively Regulates Hypersensitive Cell Death in Arabidopsis. PLoS ONE 6(4): e18750. doi: 10.1371/journal.pone.0018750. (IF, 4.411)

(8) He S., Huang K., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-type Zinc Finger Motifs of Pisum sativa LSD1 Are a Novel Nuclear Localization Signal and Interact with Importin Alpha. PLoS ONE 6(7): e22131. doi: 10.1371/journal.pone.0022131. (IF, 4.411)

(9) Qian, W., Tan, G., He, S., Zhang, X., Zhang, X., Gao, Y., Liu, H., and An, C. (2007) Identification of a new AT-rich-element binding factor PsATF1 and its combined effect with PsGBF on the activation of PsCHS1 promoter. Frontiers in Bioscience 12, 1670-1679. (IF, 4.249)

(10) Qian, W., Tan, G., Liu, H., He, S., Gao, Y., and An, C. (2007) Identification of a bHLH-type G-box binding factor and its regulation activity with G-box and Box I elements of the PsCHS1 promoter. Plant Cell Reports 26, 85-93. (IF, 3.071)

(11) Tan, G., Gao, Y., Shi, M., Zhang, X., He, S., Chen, Z., and An, C. (2005) SiteFinding-PCR: a simple and efficient PCR method for chromosome walking. Nucleic Acids Research 33, e122. (IF, 9.112)