北京理工大學(xué)化學(xué)與化工學(xué)院研究生院導(dǎo)師介紹：杜大明

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北京理工大學(xué)化學(xué)與化工學(xué)院研究生院導(dǎo)師杜大明介紹如下：

教師姓名：杜大明
出生年月：1967年11月
政治面貌：中共黨員
所在學(xué)科：應(yīng)用化學(xué)
職稱：教授，博士生導(dǎo)師
聯(lián)系電話：010-68914985/68918716
郵箱：dudm@bit.edu.cn
通訊地址：北京市海淀區(qū)中關(guān)村南大街5號
郵編：100081
 
教育經(jīng)歷

1992 年 9 月—1995 年 6 月，南開大學(xué)有機化學(xué)專業(yè)，獲得理學(xué)博士學(xué)位。
1989 年 9 月—1992 年 7 月，南開大學(xué)有機化學(xué)專業(yè)，獲得理學(xué)碩士學(xué)位。
1985 年 9 月—1992 年 7 月，鄭州大學(xué)化學(xué)專業(yè)，獲得理學(xué)學(xué)士學(xué)位。
 
工作經(jīng)歷

2008 年 9 月—目前，北京理工大學(xué)化工與環(huán)境學(xué)院
1999 年 4 月—2008 年 8 月，北京大學(xué)化學(xué)與分子工程學(xué)院
1995 年 7 月—1999 年 3 月，山東大學(xué)化學(xué)學(xué)院
（其間：香港中文大學(xué)和香港科技大學(xué)）
 
研究領(lǐng)域

不對稱催化合成；有機合成新方法和綠色化學(xué)合成；藥物及中間體合成
 
獲獎情況

1.教育部新世紀(jì)優(yōu)秀人才支持計劃獲得者
2.Thieme Journal Award 2009
3.Tetrahedron: Asymmetry Most Cited Paper 2004-2007 Award
4.第八屆北京青年優(yōu)秀科技論文評選二等獎
 
社會兼職
 
教學(xué)工作

2015 年教學(xué)工作
1.本科生《化學(xué)制藥工藝學(xué)》，32 學(xué)時；
2.本科生《學(xué)科進展報告》，2 學(xué)時；
3.  碩士研究生《高等有機化學(xué)》，54 學(xué)時
2014 年教學(xué)工作
1.本科生《化學(xué)制藥工藝學(xué)》，32 學(xué)時；
2.本科生《學(xué)科進展報告 A》，2 學(xué)時；
3.碩士研究生《高等有機化學(xué)》，54 學(xué)時
 
論文與著作

1.Jiahuan Peng, Bo-Liang Zhao, Da-Ming Du*. A combination of metal and
organocatalysis: Highly diastereo- and enantioselective construction of fluorinated
2-aminocyclopenta[b]pyran derivatives[J]. Advanced Synthesis & Catalysis, 2015,
357(16-17), 3639-3647.
2.Jun-Hua Li, Da-Ming Du*. Phosphine-catalyzed cascade reaction of unsaturated
pyrazolones with alkyne derivatives: Efficient synthesis of pyrano[2,3-c]pyrazoles
and spiro-cyclopentanone-pyrazolones[J]. Advanced Synthesis & Catalysis, 2015,
DOI: 10.1002/adsc.201500675.
3.Jun-Hua Li, Ting-Fan Feng, Da-Ming Du*. Construction of
spirocyclopropane-linked heterocycles containing both pyrazolones and oxindoles
through Michael/alkylation cascade reaction[J]. The Journal of Organic Chemistry,
2015, 80(22), 11369-11377..
4.Bo-Liang Zhao, Ye Lin, Hao-Hao Yan, and Da-Ming Du*. Squaramide-catalyzed
asymmetric cascade aza-Michael/Michael addition reaction for synthesis of chiral
trisubstituted pyrrolidines[J]. Organic & Biomolecular Chemistry, 2015, 13(46),
11351-11361.
5.Bo-Liang Zhao, Da-Ming Du*. Chiral squaramide-catalyzed Michael/alkylation
cascade reaction for the asymmetric synthesis of nitro-spirocyclopropanes[J].
European Journal of Organic Chemistry, 2015, (24), 5350-5359.
6.Bo-Liang Zhao, Da-Ming Du*. Organocatalytic enantioselective cascade
aza-Michael/Michael addition sequence for asymmetric synthesis of chiral
spiro[pyrrolidin-3,3'-oxindole]s[J]. Asian Journal of Organic Chemistry, 2015, 4(10),
1120-1126.3
7.Bo-Liang Zhao, Da-Ming Du*. Chiral-squaramide-catalyzed sulfa-Michael/aldol
cascade reactions for asymmetric synthesis of spirothiochromanones[J]. Asian
Journal of Organic Chemistry, 2015, 4(8), 778-787.
8.Jun-Hua Li, Da-Ming Du*, Enantioselective cascade double Michael addition of
3-nitro-2H-chromenes and acyclic enones: Efficient synthesis of functionalized
tricyclic chroman derivatives[J]. Organic & Biomolecular Chemistry, 2015, 13(37),
9600-9609.
9.Jun-Hua Li, Da-Ming Du*. Enantioselective synthesis of chiral heterocycles
containing both chroman and pyrazolone derivatives catalysed by a chiral
squaramide[J]. Organic & Biomolecular Chemistry, 2015, 13(20), 5636-5645.
10.Jun-Hua Li, Da-Ming Du*. Enantioselective synthesis of biologically active
dihydropyrano-[2,3-c]pyrazoles catalysed by a chiral squaramide[J]. Chinese
Journal of Chemistry, 2015, 33(4), 418–424.
11.Jun-Hua Li, Da-Ming Du*. Organocatalyzed enantioselective cascade
aza-Michael/Michael addition for the construction of highly functionalized
spiropyrazolone tetrahydroquinolines[J]. Chemistry-An Asian Journal, 2014, 9(11),
3278–3286.
12.Yu Gao, Da-Ming Du*. Asymmetric Michael addition/intramolecular cyclization
catalyzed by bifunctional tertiary amine-squaramides: construction of chiral
2-amino-4H-chromene-3-carbonitrile derivatives[J]. Chemistry-An Asian Journal,
2014, 9(10), 2970–2974.
13.Bo-Liang Zhao, Lei Liu, Da-Ming Du*. Chiral squaramide-catalyzed
sulfa-Michael/aldol cascade for the asymmetric synthesis of spirocyclic
tetrahydrothiophene chromanone derivatives[J]. European Journal of Organic
Chemistry, 2014, (35), 7850–7858.
14.Hai-Xiao He, Da-Ming Du*. Organocatalytic enantioselective Strecker reaction of
imines containing a thiazole moiety by using a cinchona-based squaramide
catalyst[J]. European Journal of Organic Chemistry, 2014, (28), 6190–6199.
15.Bo-Liang Zhao, Da-Ming Du*. Chiral squaramide-catalysed one-pot
enantioselective sulfa-Michael addition/thioesterification of thiols
with ,-unsaturated N-acylated succinimides[J]. Organic & Biomolecular Chemistry,
2014, 12(10), 1585–1594.
16.Bo-Lliang Zhao, Da-Ming Du*. Catalytic asymmetric conjugate addition of
various -mercaptoketones to ,-unsaturated N-acylated oxazolidin-2-ones with
bifunctional organocatalyst[J]. RSC Advances, 2014, 4(52), 27346–27353.
17.Jun-Hua Li, Da-Ming Du*. Enantioselective synthesis of pyrazolone derivatives
catalysed by a chiral squaramide catalyst[J]. RSC Advances, 2014, 4(28), 14538–
14545.
18.Jiahuan Peng, Da-Ming Du*. Efficient enantioselective fluorination of -keto
esters/amides catalysed by diphenylamine-linked bis(thiazoline)-Cu(OTf)2
complexes[J]. RSC Advances, 2014, 4(4), 2061–2067.
19.Ying-He Li, Bo-Liang Zhao, Yu Gao, Da-Ming Du*. Asymmetric synthesis of
3-substituted indole derivatives containing tetrahydrothiophene via cascade
Michael/Michael additions catalyzed by a chiral squaramide catalyst[J].
Tetrahedron:Asymmetry, 2014, 25(23), 1513–1519.
20.Sheng-Jian Jia, Da-Ming Du*. Enantioselective Friedel-Crafts alkylation of
indoles with  β,γ-unsaturated α-ketoesters catalyzed  by new squaramide-linked
bisoxazoline-Zn(OTf)2 complexes[J]. Tetrahedron:Asymmetry, 2014, 25(13-14), 980
–988.
21.Hai-Xiao He, Da-Ming Du*. Highly enantionselective Mannich reaction of imines
with tert-butyl acetoacetate catalysed by squaramide[J]. Tetrahedron: Asymmetry
2014, 25(8), 637–643.
22.Bo-Liang Zhao, Da-Ming Du*. Enantioselective synthesis of enol lactones from
tandem Michael addition/lactonization catalyzed by chiral squaramide catalyst[J].
Tetrahedron: Asymmetry, 2014, 25(4), 310–317.
23.Yi Yang, Daming Du*. Enantioselective construction of functionalized
thiochromans via squaramide-catalyzed asymmetric cascade
sulfa-Michael/Michael addition[J]. Chinese Journal of Chemistry 2014, 32(9), 853–
858.
24.Sheng-Jian Jia, Da-Ming Du*. Enantioselective chlorination of -keto esters and
amides catalyzed by chiral copper(II) complexes of squaramide-linked bisoxazoline
ligand[J]. Chinese Chemical Letters, 2014, 25(11), 1479–1484.
25.Wen Yang, Da-Ming Du*. Cinchona-based squaramide-catalysed cascade
aza-Michael-Michael addition: enantioselective construction of functionalized
spirooxindole tetrahydroquinolines[J]. Chemical Communications, 2013, 49(78),
8842–8844.
26.Wen Yang, Yi Yang, Da-Ming Du*. Squaramide-tertiary amine catalyzed
asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution:
access to highly functionalized chromans with three contiguous stereocenters[J].
Organic Letters, 2013, 15(6), 1190–1193.
27.Wen Yang, Hai-Xiao He, Yu Gao, Da-Ming Du*. Organocatalytic enantioselective
cascade aza-Michael/Michael addition for the synthesis of highly functionalized
tetrahydroquinolines and tetrahydrochromanoquinolines[J]. Advanced Synthesis &
Catalysis, 2013, 355(18), 3670–3678.
28.Hai-Xiao He, Wen Yang, Da-Ming Du*. Enantioselective aza-Henry reaction of
imines bearing a benzothiazole moiety catalyzed by a cinchona-based
squaramide[J]. Advanced Synthesis & Catalysis, 2013, 355(6), 1137–1148.
29.Jun-Hua Li, Da-Ming Du*. Squaramide-catalysed enantioselective Michael
addition of pyrazolin-5-ones to nitroalkenes[J]. Organic & Biomolecular Chemistry,
2013, 11(36), 6215–6223.
30.Jianhuan Peng, Da-Ming Du*. Catalytic asymmetric tandem Friedel-Crafts
alkylation/ Michael addition reaction for the synthesis of highly functionalized
chromans[J]. Beilstein Journal of Organic Chemistry, 2013, 9, 1210–1216.
31.Hai-Xiao He, Da-Ming Du*. Squaramide-catalysed enantionselective Mannich
reaction of imines bearing a heterocycle with malonates[J]. RSC Advances, 2013,
3(37), 16349–16358.
32.Yang Jia, Da-Ming Du*. Catalyst-free, one-pot three-component 1,3-dipolar
cycloaddition of diethyl 2-aminomalonate, benzaldehydes and
3-nitro-2H-chromenes[J]. RSC Advances, 2013, 3(6), 1970–1975.
33.Yu Gao, Da-Ming Du*. Facile synthesis of chiral
2-amino-4-(indol-3-yl)-4H-chromene derivatives using thiourea as the catalyst[J].
Tetrahedron: Asymmetry, 2013, 24(20), 1312–1317.
34.Juan Dong, Da-Ming Du*. Highly enantioselective synthesis of Warfarin and its
analogs catalysed by primary amine-phosphinamide bifuncitonal catalysts[J].
Organic & Biomolecular Chemistry, 2012, 10(40), 8125–8131.
35.Wen Yang, Da-Ming Du*. Squaramide-catalysed enantio- and diastereoselective
sulfa-Michael addition of thioacetic acid to  α,β-disubstituted nitroalkenes[J].
Organic & Biomolecular Chemistry, 2012, 10(34), 6876–6884.
36.Yang Jia, Wen Yang, Da-Ming Du*. Asymmetric Friedel-Crafts alkylation of
indoles with 3-nitro-2H-chromenes catalyzed by diphenylamine-linked
bis(oxazoline) and bis(thiazoline) Zn(II) complexes[J]. Organic & Biomolecular
Chemistry, 2012, 10(24), 4739–4746.
37.Chunhua Luo, Yu Jin, Da-Ming Du*. Simple chiral sulfonamide primary amine
catalysed highly enantioselective Michael addition of malonates to enones[J].
Organic & Biomolecular Chemistry, 2012, 10(20), 4116–4123.
38.Wen Yang, Yang Jia, Da-Ming Du*. Chiral squaramide-catalyzed enantioselective
Michael addition of malonitrile to chacones[J]. Organic & Biomolecular Chemistry,
2012, 10(2), 332–338.
39.Jiahuan Peng, Da-Ming Du*. Asymmetric Friedel-Crafts alkylation of indoles with
nitrodienes and 2-propargyloxy-β-nitrostyrenes catalyzed by
diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complexes[J]. European Journal of
Organic Chemistry, 2012, (21), 4042–4051.
40.Yu Jin, Da-Ming Du*. The synthesis of phosphine oxide-linked bis(oxazoline)
ligands and their application in asymmetric allylic alkylation[J]. Tetrahedron, 2012,
68(18), 3633–3640.
41.Wen Yang, Jingsi Wang, Da-Ming Du*. Chiral squaramide-catalyzed enantio-
and diastereoselective Michael addition of 3-substituted oxindoles to
nitroalkenes[J]. Tetrahedron: Asymmetry, 2012, 23(13), 972–980.
42.Yu Gao, Da-Ming Du*. Enantioselective synthesis of
2-amino-5,6,7,8-tetrahydro-5-oxo-4H-chromene-3-carbonitriles using squaramide
as the catalyst[J]. Tetrahedron: Asymmetry, 2012, 23(18-19), 1343–1349.
43.Yu Gao, Wen Yang, Da-Ming Du*. Efficient organocatalytic asymmetric synthesis
of 2-amino-4H-chromene-3-carbonitrile derivatives[J]. Tetrahedron: Asymmetry,
2012, 23(5), 339–344.
44.Shengjian Jia, Chunhua Luo, Daming Du*. Highly enantioselective Michael
addition of ketone to alkylidene malonates catalyzed by binaphthyl sulfonimides in
water[J]. Chinese Journal of Chemistry, 2012, 30(11), 2676–2680.
45.Wen Yang, Da-Ming Du*. Chiral squaramide-catalyzed highly diastereo- and
enantioselective direct Michael addition of nitroalkanes to nitroalkenes[J]. Chemical
Communications, 2011, 47(47), 12706–12708.
46.Wen Yang, Da-Ming Du*. Chiral squaramide-catalyzed highly enantioselective
Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes[J]. Advanced
Synthesis & Catalysis, 2011, 353(8), 1241–1246.
47.Wen Yang, Da-Ming Du*. Highly enantioselective Henry reaction catalyzed by
C2-symmetric modular BINOL-oxazoline Schiff base copper(II) complex generated
in situ[J]. European Journal of Organic Chemistry, 2011, (8), 1552–1556.
48.Xian Du, Han Liu, Da-Ming Du*. Synthesis and application of diphenyl sulfide
linked bis(imidazoline) ligands: Dramatic electronic effect of ligands on catalytic
behavior[J]. European Journal of Organic Chemistry, 2011, (4), 786–793.
49.Chunhua Luo, Da-Ming Du*. Highly enantioselective Michael addition of
ketones and an aldehyde to nitroalkenes catalyzed by a binaphthyl sulfonimide in
water[J]. Synthesis, 2011, (12), 1968–1973.
50.Wen Yang, Da-Ming Du*. Highly enantioselective Michael addition of
nitroalkanes to chalcones using chiral squaramides as hydrogen bonding
organocatalysts[J]. Organic Letters, 2010, 12(23), 5450–5453.
51.Han Liu, Da-Ming Du*. Development of diphenylamine-linked bis(imidazoline)
ligands and their application in asymmetric Friedel-Crafts alkylation of indole
derivatives with nitroalkenes[J]. Advanced Synthesis & Catalysis, 2010, 352(7), 1113
–1118.
52.Wen Yang, Han Liu, Da-Ming Du*. Efficient in situ three-component formation of
chiral oxazoline-Schiff base copper(II) complexes: towards combinatorial library of
chiral catalysts for asymmetric Henry reaction[J]. Organic & Biomolecular Chemistry,
2010, 8(13), 2956–2960.
53.Shurong Ban, Da-Ming Du*, Han Liu, Wen Yang. Synthesis of novel binaphthyl
sulfonimides and their application in the enantioselective Michael addition of
ketones to nitroalkenes[J]. European Journal of Organic Chemistry, 2010, (27), 5160
–5164.
54.Han Liu, Da-Ming Du*. Immobilization of diphenylamine-linked bis(oxazoline)
ligands and their application in asymmetric Friedel-Crafts alkylation of indole
derivatives with nitroalkenes[J]. European Journal of Organic Chemistry, 2010, (11),
2121–2131.
55.Xian Du, Han Liu, Da-Ming Du*. Rational tuning the rigidity of a ligand scaffold:
synthesis of diphenylsulfide-linked bis(oxazoline) ligands and their application in
asymmetric allylic alkylation[J]. Tetrahedron: Asymmetry, 2010, 21(2), 241–246.
56.Han Liu, Neng-Dong Wng, Da-Ming Du*. Direct experimental evidence for the
priority of flexible ligand skeleton in asymmetric Friedel-Crafts alkylation of indole
with nitroalkenes[J]. Letters in Organic Chemistry, 2010, 7(2), 114–120.
57.Han Liu, Da-Ming Du*. Recent advances in the synthesis of 2-imidazolines and
their applications in homogeneous catalysis[J]. Advanced Synthesis & Catalysis,
2009, 351(4), 489–519.
58.Wei Li, Han Liu, Da-Ming Du*. Mild michael addition of glycine imines to
aromatic nitroalkenes catalyzed by DBU with LiOTf as an additive[J]. Synlett, 2009,
(6), 925–928.
59.Jin Wang, Han Liu, Da-Ming Du*. Diphenylamine-derived bis-hydroxyamide
catalyzed asymmetric borane reduction of prochiral ketones[J]. Tetrahedron:
Asymmetry, 2009, 20(5), 605–609.
60.Qun-Sheng Guo, Da-Ming Du*. The practical synthesis of double axial chiral
guanidines[J]. Letters in Organic Chemistry, 2009, 6(3), 197–202.
61.Han Liu, Wei Li, DaMing Du*. Modification of diphenylamine-linked
bis(oxazoline) ligands: tuning of electronic effect and rigidity of ligand skeleton[J].
Science in China Series B: Chemistry, 2009, 52(9), 1321–1330.
62.Ning Chen, Min Zhu, Wei Zhang, Da-Ming Du, Jiaxi Xu*. Synthesis of
gem-disubstituted taurines by the regioselective ring-opening of 2,2-disubstituted
aziridines with sodium bisulfite and sulfite[J]. Amino acids, 2009, 37(2), 309-313.
63.Qun-Sheng Guo, Da-Ming Du*, Jiaxi Xu. The development of new double axially
chiral phosphoric acids and their catalytic asymmetric transfer hydrogenation of
quinolines[J]. Angewandte Chemie, International Edition, 2008, 47(4), 759–762.
64.Wen-Ming Zhou, Han Liu, Da-Ming Du*. Organocatalytic highly enantioselective
Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes[J]. Organic
Letters, 2008, 10(13), 2817–2820.
65.Han Liu, Shao-Feng Lu, Jiaxi Xu, Da-Ming Du*. Asymmetric Friedel-Crafts
alkylation of electron-rich N-heterocycles with nitroalkenes catalyzed by
diphenylamine-tethered bis(oxazoline) and bis(thiazoline)-Zn(II) complexes[J].
Chemistry-An Asian Journal, 2008, 3(7), 1111–1121.
66.Huihui?Li, Gu Yuan,* Daming Du. Investigation of formation, recognition,
stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase
inhibitors by electrospray ionization mass spectrometry[J]. Journal of the American
Society of Mass Spectrometry, 2008, 19(4), 550–559.
67.Boyuan Wang, Wei Zhang, Leilei Zhang, Da-Ming Du, Gang Liu, Jiaxi Xu*.
Versatile synthesis of free and N-benzyloxycarbonyl protected 2,2-disubstituted
taurines[J]. European Journal of Organic Chemistry, 2008, (2), 350–355.
68.Juanjuan Du, Zhiyi Li, Da-Ming Du, Jiaxi Xu*. Unexpected influence and its origin
in rationally tuning the electronic effect of catalysts in the asymmetric borane
reduction of ketones[J]. Journal of Molecular Catalysis A: Chemistry, 2008, 284(1),
40–45.
69.Wei Zhang, Boyuan Wang, Ning Chen, Da-Ming Du, Jiaxi Xu*. Expeditious and
practical synthesis of various substituted taurines from amino alcohols[J]. Synthesis,
2008, (2), 197–200.
70.Min Zhu, Libo Hu, Ning Chen, Da-Ming Du, and Jiaxi Xu*. Synthesis of
NH-aziridines from vicinal amino alcohols via the Wenker reaction: scope and
limitation[J]. Letters in Organic Chemistry, 2008, 5(3), 212–217.
71.Juanjuan Du, Zhiyi Li, Da-Ming Du, Jiaxi Xu*. Improving enantioselectivity via
rationally tuning electronic effects of catalysts in the organocatalytic asymmetric
aldol reaction[J]. Arkivoc, 2008, Part (xvii), 145–156.
72.Han Liu, Jiaxi Xu, Da-Ming Du*. Asymmetric Friedel-Crafts alkylation of
methoxyfuran with nitroalkenes catalyzed by diphenylamine-tethered
bis(oxazoline)-Zn(II) complexes[J]. Organic Letters, 2007, 9(23), 4725–4728.
73.Libo Hu, Hui Zhu, Da-Ming Du, Jiaxi Xu*. Efficient synthesis of taurine and
structurally diverse substituted taurines from aziridines[J]. The Journal of Organic
Chemistry, 2007, 72(12), 4543–4546.
74.Bonan Li, Shuzong Cai, Da-Ming Du, Jiaxi Xu*. Synthesis of phosphinopeptides
via the Mannich ligation[J]. Organic Letters, 2007, 9(12), 2257–2260.
75.Bonan Li, Yikai Wang, Da-Ming Du, Jiaxi Xu*. Notable and obvious ketene
substituent-dependent effect of temperature on the stereoselectivity in the
Staudinger reaction[J]. The Journal of Organic Chemistry, 2007, 72(3), 990–997.
76.Libo Hu, Yikai Wang, Bonan Li, Da-Ming Du, Jiaxi Xu*. Diastereoselectivity in the
Staudinger reaction: a useful probe for investigation of nonthermal microwave
effects[J]. Tetrahedron, 2007, 63(38), 9387–9392.
77.Linge Ma, Peng Jiao, Qihan Zhang, Da-Ming Du, Jiaxi Xu*. Ligand and substrate
pi-stacking interaction controlled enantioselectivity in the catalytic asymmetric
aziridination[J]. Tetrahedron: Asymmetry, 2007, 18(7), 878–884.
78.Xiao Wang, Han Liu, Da-Ming Du, Jiaxi Xu*. Effect of the borane source on the
enantioselectivity in the chiral oxazaborolidine-catalyzed asymmetric borane
reduction of ketones[J]. Heteroatom Chemistry, 2007, 18(7), 740–746.
79.李伯男，梁勇，焦雷，胡立博，杜大明，許家喜*. 3-(噻吩-2-基)-β-內(nèi)酰胺的合成及其立
體化學(xué)[J].  化學(xué)學(xué)報, 2007, 65(16), 1643–1648.
80.Shao-Feng Lu, Da-Ming Du*, Jiaxi Xu, Shi-Wei Zhang. Asymmetric conjugate
addition of nitroalkanes to nitroalkenes catalyzed by C2-symmetric tridentate
bis(oxazoline) and bis(thiazoline) zinc complexes[J]. Journal of the American
Chemical Society, 2006, 128(23), 7418–7419.
81.Shao-Feng Lu, Da-Ming Du*, Jiaxi Xu. Enantioselective Friedel-Crafts alkylation
of indoles with nitroalkenes catalyzed by bifunctional tridentate bis(oxazoline)-Zn(II)
complex[J]. Organic Letters, 2006, 8(10), 2115–2118.
82.Da-Ming Du*, Tao Fang, Jiaxi Xu, Shi-Wei Zhang. Structurally well-defined,
recoverable C3-symmetric tris(-hydroxy phosphoramide)-catalyzed
enantioselective borane reduction of ketones[J]. Organic Letters, 2006, 8(7), 1327–
1330.
83.Tao Fang, Jiaxi Xu, Da-Ming Du*. Highly enantioselective borane reduction of
prochiral ketones catalyzed by C3-symmetric tripodal -hydroxy amides[J]. Synlett,
2006, (10), 15591563.
84.Tao Fang, Jiaxi Xu, Da-Ming Du*. Facile synthesis of C3-symmetric tripodal
-hydroxy amide ligands and their Ti (IV) complex-catalyzed asymmetric addition of
diethylzinc to aldehydes[J]. Letters in Organic Chemistry, 2006, 3(10), 780–786.
85.Yikai Wang, Yong Liang, Lei Jiao, Da-Ming Du, Jiaxi Xu*. Do reaction conditions
affect the stereoselectivity in the Staudinger reaction?[J]. The Journal of Organic
Chemistry, 2006, 71(18), 69836990.
86.Linge Ma, Da-Ming Du, Jiaxi Xu. Asymmetric aziridination of 1,3-dienes
catalyzed by bisoxazoline-copper complexes[J]. Chirality, 2006, 18(8), 575–580.
87.Xiao Wang, Yikai Wang, Da-Ming Du, Jiaxi Xu*. Solvent-free, AlCl3-promoted
tandem Friedel-Crafts reaction of arenes and aldehydes[J]. Journal of Molecular
Catalysis A: Chemistry, 2006, 255(1-2), 31–35.
88.Jiaxing Huang, Da-Ming Du, Jiaxi Xu*. Facile synthesis of 1,1-disubstituted
taurines[J]. Synthesis, 2006, (2), 315–319.
89.Han Liu, Da-Ming Du, Jiaxi Xu*. Effect of the secondary reduction on the
enantioselectivity and function of additives in the oxazaborolidine-catalyzed
asymmetric borane reduction of ketones[J]. Helvetica Chimica Acta, 2006, 89(5),
1067–1074.
90.馬琳鴿,  杜大明, 許家喜.  在不對稱氮雜環(huán)丙烷化中雙噁唑啉配位空間大小對對映選擇
性的影響[J].  有機化學(xué), 2006, 26(4), 568–572.
91.王一愷,  杜大明, 許家喜*.  微波對烯酮和亞胺形成-內(nèi)酰胺順反選擇性的影響[J].  遼寧石
油化工大學(xué)學(xué)報, 2006, 26(4), 94–95, 99.
92.Tao Fang, Da-Ming Du,* Shao-Feng Lu, Jiaxi Xu*. Synthesis of C3-Symmetric
tris(-hydroxy amide) ligands and their Ti(IV) complex-catalyzed enantioselective
alkynylation of aldehydes[J]. Organic Letters, 2005, 7(11), 2081–2084.
93.Da-Ming Du,* Shao-Feng Lu, Tao Fang, Jiaxi Xu*. Asymmetric Henry reaction
catalyzed by C2-symmetric tridentate bis(oxazoline) and bis(thiazoline) complexes:
metal-controlled reversal of enantioselectivity[J]. The Journal of Organic Chemistry,
2005, 70(9), 3712–3715.
94.Linge Ma, Da-Ming Du, Jiaxi Xu*. Rational tuning chelate size of bis-oxazoline
ligands to improve enantioselectivity in the asymmetric aziridination of
chalcones[J]. The Journal of Organic Chemistry 2005, 70 (24), 10155–10158.
95.Jiaxing Huang, Fei Wang, Da-Ming Du, Jiaxi Xu*. An expeditious synthesis of
1-substituted and cyclic taurines[J]. Synthesis, 2005, (13), 2122–2128.
96.Zhan-Yue Wang, Da-Ming Du*, Jia-Xi Xu. Synthesis of novel chiral semicrown
ether-like bis(oxazoline) ligands and application in enantioselective
cyclopropanation of styrene[J]. Synthetic Communications, 2005, 35(2), 299–313.
97.Hui Chen, Da-Ming Du, Bin Fu, Meiyu He. Investigation on mass spectra
fragmentation mechanism of C2-symmetric chiral bis(oxazolines) and
bis(thiazolines)[J]. Chinese Journal of Chemistry, 2005, 23(6), 720–724.
98.Da-Ming Du, Paul R. Carlier*. Development of bivalent acetylcholinesterase
inhibitors as potential therapeutic drugs for alzheimer’s disease[J]. Current
Pharmaceutical Design, 2004, 10(25), 3141–3156.
99.Shao-Feng Lu, Da-Ming Du,* Shi-Wei Zhang, Jiaxi Xu*. Facile synthesis of
C2-symmetric tridentate bis(thiazoline) and bis(oxazoline) ligands and their
application in the enantioselective Henry reaction[J]. Tetrahedron: Asymmetry,
2004, 15 (21), 3433–3441.
100.Bin Fu, Da-Ming Du*, Jianbo Wang. Synthesis of novel C2-symmetric chiral
bis(oxazoline) ligands and their application in the enantioselective addition of
diethylzinc to aldehydes[J]. Tetrahedron: Asymmetry, 2004, 15(1), 119–126.
101.Bin Fu, Da-Ming Du,* Qing Xia. C2-symmetric chiral bis(thiazoline) and
bis(oxazoline) ligands and their application in the catalytic allylic alkylation[J].
Synthesis, 2004, (2), 221–226.
102.Yong-Xin Zhang, Da-Ming Du,* Xiao Chen, Shao-Feng Lü, Wen-Ting Hua.
Enantiospecific synthesis of pyridinylmethyl pyrrolidinemethanols and catalytic
asymmetric borane reduction of prochiral ketones[J]. Tetrahedron: Asymmetry,
2004, 15(1), 177–182.
103.Bin Fu, Da Ming Du,* Qing Xia. Convenient synthesis of bis(oxazoline)
dicarboxylate derivatives[J]. Chinese Chemical Letters, 2004, 15 (4), 383–
385.
104.Xiao Chen, Yong Xin Zhang, Da Ming Du, Wen Ting Hua*. New chiral pyridine
prolinol derivatives and preliminary study on asymmetric catalytic reaction[J].
Chinese Chemical Letters, 2004, 15(2), 167–168.
105.Weifeng Shi, Nan Jiang, Shiwei Zhang, Weiming Wu, Daming Du, Jianbo Wang*.
Unusual reaction of beta-hydroxy alpha-diazo carbonyl compounds with
Cl3CCN/NaH and Rh(II)-catalyzed reaction of beta-trichloroacetylamino
alpha-diazo carbonyl compounds[J]. Organic Letters, 2003, 5(13), 2243–2246.
106.Da-Ming Du,* Bin Fu, Wen-Ting Hua. Novel chiral dibenzo[a,c]cycloheptadiene
bis(oxazoline) and catalytic enantioselective cyclopropanation of styrene[J].
Tetrahedron, 2003, 59(11),1933–1938.
107.Xiao Chen, Da-Ming Du, Wen-Ting Hua*. Synthesis of novel chiral polyamide
macrocycles containing pyridyl side-arm and their molecular recognition
properties[J]. Tetrahedron: Asymmetry, 2003, 14(8), 999–1007.
108.Dong-Cheng Xu, Da-Ming Du,* Nan Ji, Zhan-Yue Wang, Wen-Ting Hua.
Synthesis of novel chiral C2-symmetric bisoxazoline ligands containing
2,5-di(m-substituted)phenyl-1,3,4-oxadiazole[J]. Synthetic Communications, 2003,
33(14), 2563–2574.
109.Zhan-Yue Wang, Da-Ming Du,* Di Wu, Wen-Ting Hua*. Studies on the
synthesis of novel chiral naphthylene bisoxazoline ligands[J]. Synthetic
Communications, 2003, 33(8), 1275–1283.
110.Hui Chen, Da-Ming Du, Wen-Ting Hua, Meiyu He,* Bin Xin. Study of the
fragmentation mechanism of novel functionalized macrocycles by Fourier
transform ion cyclotron resonance mass spectrometry[J]. Journal of Mass
Spectrometry, 2003, 38(8), 839–844.
111.Bin Fu, Da-Ming Du*. Asymmetric Diels-Alder reaction catalyzed by novel chiral
dibenzo[a, c]cycloheptadiene bis(oxazoline) metal complexes[J]. Chinese Journal of
Chemistry, 2003, 21(6), 597–599.
112.杜大明,*  陳曉, 花文廷.  離子液體介質(zhì)中有機合成及催化不對稱反應(yīng)研究新進展[J].  有
機化學(xué), 2003, 23(4), 331–343.
113.杜大明,*  花文廷. 大環(huán)手性磷酰胺對氨基酸衍生物的分子識別研究[J].  高等學(xué)�；瘜W(xué)
學(xué)報, 2003, 24(3), 442–448.
114.Zhan-Yue Wang, Da-Ming Du,* Di Wu, Wen-Ting Hua, Xiang-Lin Jin. Synthesis
and Crystal Structure of N-(1’-Phenyl-2’
-hydroxyethyl)-2,3-naphthylenedicarboximide[J]. Chemical Research in Chinese
Universities, 2003, 19(2), 160–164.
115.Da-Ming Du,* Xiao Chen, Wen-Ting Hua, Xiang-Lin Jin. Reinvestigation the
reaction of salicyclic chloride with salicyclic amide and X-ray crystal structure of a
new macrocyclic polyester[J]. Chinese Journal of Structural Chemistry, 2003, 22(5),
512–516.
116.Hai-Chen Wu, Da-Ming Du, Wen-Ting Hua,* Xiang-Lin Jin. Synthesis and crystal
structure of novel chiral o-hydroxyphenyloxazoline metal complexes[J]. Chinese
Journal of Structural Chemistry, 2003, 22(2), 155–160.
117.Da-Ming Du,* Zhan-Yue Wang, Dong-Cheng Xu, Wen-Ting Hua. Synthesis of
novel chiral bisoxazoline ligands containing 2,5-diaryl-1,3,4-oxadiazole and
enantioselective cyclopropanation of styrene[J]. Synthesis, 2002, (16), 2347–2352.
118.Xiao Chen, Da-Ming Du, Wen-Ting Hua*. A convenient method for synthesis of
trans-4-cyclohexyl-L-proline[J]. Tetrahedron: Asymmetry, 2002, 13(1), 43–46.
119.Xiao Chen, Da Ming Du, Wen Ting Hua*. Synthesis of novel C2-symmetric chiral
polyamide macrocycles containing pyridyl side-arm[J]. Chinese Chemical Letters,
2002, 13(11), 1037–1038.
120.杜大明,*  花文廷. 催化不對稱 Michael 加成反應(yīng)的新進展[J].  有機化學(xué), 2002, 22(3),
164–173.
121.周靈萍,  杜大明, 李宣文,*  王少坤,  周愛秋,  劉建. NaBr/KZSM-5 催化劑在甲苯氧化甲
基化反應(yīng)中的催化性能[J].  北京大學(xué)學(xué)報(自然科學(xué)版), 2002, 38(2), 153–158.
122.Da-Ming Du,* Wen-Ting Hua. One-pot synthesis of macrocyclic chiral
phosphoramidates[J]. Synthetic Communications, 2001, 31(20), 3197–3203.
123.Da-Ming Du,* Wen-Ting Hua, Xiang-Ling Jin. Synthesis and crystal structure of
two new macrocyclic phosphoramidates containing glycine ethyl ester and
2,5-diaryl-1,3,4-oxadiazole[J]. Journal of Molecular Structure, 2001, 561(1-3), 145–
152.
124.Da-Ming Du,* Wen-Ting Hua, Zhe-Ming Wang, Chun-Hua Yan. New chiral
macrocyclic phosphoramidate self-associated by an intermolecular N-HO=P
hydrogen bond[J]. Heteroatom Chemistry, 2001, 12(6), 480–484.
125.Da-Ming Du,* Wen-Ting Hua, Ling-Ping Zhou, Jian-Wu Wang, Xiang-Lin Jin.
Preparation and crystal structure of a 1:1 inclusion compound of
1,4,11,14-tetramethoxy-dibenzo[b,n]tetraphenylene with pyridine[J]. Journal of
Molecular Structure, 2001, 560(1-3), 23–28.
126.杜大明,*  王永梅, 孟繼本,  周秀中.  雙核有機金屬化合物的光化學(xué)反應(yīng)[J]. 有機化學(xué),
2001, 21(5), 350–355.
127.Paul R. Carlier,* Da-Ming Du, Yi-Fan Han, Jing Liu, Emanuele Perola, Ian D.
Williams, Yuan-Ping Pang. Dimerization of an inactive fragment of Huperzine A
produces a drug with twice the potency of the natural product[J]. Angewandte
Chemie, International Edition, 2000, 39(10), 1775–1777.
128.Da-Ming Du,* Wen-Ting Hua, Jian-Wu Wang, Xiang-Lin Jin. Syntheses and
molecular self-assembly of chiral phosphoramdates[J]. Chinese Journal of
Chemistry, 2000, 18(5), 764–769.
129.Da-Ming Du,* Lin-Ping Zhou, Jian-Wu Wang, Shao-Kun Wang. Practical
synthesis of new functionalized tetraphenylenes[J]. Chinese Journal of Chemistry,
2000, 18(3), 441–443.
130.Wei Liu, Jianzhuang Jiang,* Daming Du, Ddennis P. Arnold. Synthesis and
spectroscopic properties of homoleptic bis(octakis(octyloxy)phthalocyaninato) rare
earth (III) sandwich complexes[J]. Australian Journal of Chemistry, 2000, 53(2), 131–
135.
131.Tebello Nyokong, Fumio Furuya, Nagao Kobayashi, Daming Du, Wei Liu,
Jianzhuang Jiang*. Comparative spectroscopic and electrochemical properties of
bis(octakis-(dodecylthio)naphthalocyaninato) europium (III) and
bis(tetra-tert-butylnaphthalocyaninato) europium(III) complexes[J]. Inorganic
Chemistry, 2000, 39(1), 128–135.
132.Jianzhuang Jiang,* Wei Liu, Ka-Wo Poon, Daming Du, Dennis P. Arnold, Dennis
K. P. Ng. Synthesis, spectroscopic, and electrochemical properties of rare earth
double-deckers with tetra(tert-butyl)-2,3-naphthalocyaninato ligands[J]. European
Journal of Inorganic Chemistry, 2000, (1), 205–209.
133.Xiao-Ping Yang, Da-Ming Du, Qi Li, Thomas C. W. Mak, Henry N. C. Wong*.
Synthesis, structure and inclusion properties of
1,4,15,18-tetrahedro-1,4,15,18-tetraoxodibenzo-[b,h]tetraphenylene[J]. Chemical
Communications, 1999, (16), 1607–1608.
134.Paul R. Carlier,* Da-Ming Du, Yifan Han, Jing Liu, Yuan-Ping Pan. Potent, easily
synthesized Huperzine A-Tacrine hybrid acetylcholinesterase inhibitors[J].
Bioorganic & Medicinal Chemistry Letters,1999, 9(16), 2335–2338.
135.Jianzhuang Jiang,* Daming Du, M. T. M. Choi, J. L. Xie, Dennis K. P. Ng.
Synthesis and spectroscopic characterization of heteroleptic Europium(III)
double-deckers containing 2,3-naphthalo-cyaninato and tetra(4-pyridyl)-
porphyrinato ligands[J]. Chemical Letters, 1999, (3), 261–262.
136.姜建壯,*  吳基培, 杜大明,  孫思修   三明治型金屬卟啉、酞菁配合物功能材料[J].  大學(xué)
化學(xué), 1999, 14(2), 5–8.
137.Da-Ming Du, Feng Xue, Henry N. C. Wong,* Thoms C. W. Mak. Reaction of
2-methylnaphthalene with hexachlorocyclopentadiene and structural
characterization of a new addition-substitution product[J]. Journal of Chemical
Crystallography, 1998, 28(11), 787–790.
138.Da-Ming Du,* Ling-Ping Zhou, Yong-Mei Wang, Ji-Ben Meng. Synthesis and
photoreaction of polymethylenediamine bis(4-methyl-7-coumarinyl)oxyacetic
amides[J]. Chinese Journal of Chemistry, 1998, 16(5), 468–472.
139.Yong-Mei Wang, Zhong Wen, Xiao-Min Chen, Da-Ming Du, T. Matsuura, Ji-Ben
Meng*. Research on photochemical and thermochemical reactions between indole
and quinones in the absence of solevent[J]. J. Heterocyclic Chemistry, 1998, 35(2),
313–316.
140.杜大明*,  王永梅, 孟繼本.  微環(huán)境對長鏈香豆素酯光化學(xué)和光物理過程的影響[J].  高等
學(xué)�；瘜W(xué)學(xué)報, 1998, 19(10), 1611–1613.
141.杜大明,*  周靈萍, 孟繼本,  王永梅.  微環(huán)境條件影響的光化學(xué)反應(yīng)研究進展[J].合成化
學(xué), 1998, 6(3), 265–271.
142.杜大明,  王永梅, 張慧萍,  孟繼本,*  周秀中.  非共軛雙發(fā)色團體系的光化學(xué) I.  雙香豆
素氧乙酸多次甲基二醇酯的合成及光反應(yīng)研究[J].  化學(xué)學(xué)報, 1997, 55(2), 189–195.
143.王永梅,  杜大明, 李曉陸,  孟繼本,*  周秀中.  微環(huán)境影響下的乙�；�香豆素與吲哚的固
相光反應(yīng)[J].  有機化學(xué), 1997, 17(5), 433–437.
144.Yong-Mei Wang, Da-Ming Du, Ji-Ben Meng,* Xiu-Zhong Zhou, Lei Wang.
Photochemistry of nonconjugated bischromophoric systems III. Synthesis and
photoreaction of poly(ethylene glycol) biscoumarinyloxyacetates[J]. Chinese
Journal of Chemistry, 1997, 15(2), 169–173.
145.Xiao-Liu Li, Da-Ming Du, Yong-Mei Wang, Ji-Ben Meng*. Solid state reactions
of nitrogenous heterocyclic compounds I. Solid state reactions of
3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds[J]. Science in China
(Series B), 1997, 40(2), 205–214.
146.Xiao-Liu Li, Yong-Mei Wang, Da-Ming Du, Zhong Wen, Guo-Xiang Xiong,
Ji-Ben Meng*. Solid state reactions of nitrogenous heterocyclic compounds II. Solid
state reactions of indole and carbonyl compounds[J]. Science in China (Series B),
1997, 40(3), 270–277.
147.杜大明,  王永梅, 孟繼本,*  周秀中,  王國昌,  梁麗君, 高煥.  非共軛雙發(fā)色團體系的光
化學(xué)(II)  長鏈雙香豆素的光環(huán)化反應(yīng)和熒光光譜研究[J]. 高等學(xué)校化學(xué)學(xué)報, 1996, 17(7),
1074–1077.
148.杜大明,  王永梅, 孟繼本*,  周秀中,  張慧萍.  乙�；�香豆素及其衍生物與吲哚的固相光
反應(yīng)研究[J].  高等學(xué)校化學(xué)學(xué)報, 1996, 17(2), 252–254.
149.杜大明,  王永梅, 孟雙明,  梁樹森,  孟繼本,* 周秀中.  1-苯基-3-甲基-5-吡唑啉酮與二
羰基化合物的固相反應(yīng)研究[J].  高等學(xué)�；瘜W(xué)學(xué)報, 1996, 17(1), 81–84.
150.Yong-Mei Wang, Da-Ming Du, Xiao-Min Chen, Ji-Ben Meng,* Hui-Ping Zhang.
Photochemical and thermal reactions of quinones with p-chlorothiophenol in solid
state and in solution[J]. Chemical Research in Chinese Universities, 1996, 12(3), 235
–239.
151.Huan Gao,   Guo-Chang Wang, Li-Jun Liang, Bin-Lin He, Da-Ming Du,
Yong-Mei Wang, Ji-Ben Meng*. Microenvironmental effect on the intramolecular
photochemical interaction of biscoumarinyl compounds containing alkyl chains[J].
Chinese Chemical Letters, 1996, 7(8), 753–755.
152.Da-Ming Du, Yong-Mei Wang, Ji-Ben Meng,* Shuang-Ming Meng, Xiu-Zhong
Zhou, Hong-Gen. Photocycloaddition of (4-methyl-7-coumarinyl)oxyacetic acid
propanediol diester and X-ray crystal structure of product[J]. Chinese Journal of
Structural Chemistry, 1995, 14(4), 272–276.
153.Da-Ming Du, Shuang-Ming Meng, Yong-Mei Wang, Ji-Ben Meng,* Xiu-Zhong
Zhou, Ying Zhu. Solid state synthesis and crystal structure of
3-methyl-1-phenyl-4-phenylbenzoyl-methylene-5-pyrazolone[J]. Chinese Journal
of Structural Chemistry, 1995, 14(4), 277–280.
154.Da-Ming Du, Shuang-Ming Meng, Yong-Mei Wang, Ji-Ben Meng,* Xiu-Zhong
Zhou. Solid state reaction of aromatic ketones with heteroaromatics[J]. Chinese
Journal of Chemistry, 1995, 13(6), 520–524.
155.Da-Ming Du, Yong-Mei Wang, Guo-Xiang Xiong, Wen-Guang Wang, Ji-Ben
Meng*. Solid state photochemistry of nitrobenzaldehydes[J]. Chemical Research in
Chinese Universities 1995, 11(2), 111–116.
156.孟繼本,*  王文廣, 杜大明,  熊國祥,  王永梅. 含氮雜環(huán)化合物的固相光化學(xué)[J].  化學(xué)學(xué)報, 1995, 53(6), 595–602.
157.孟繼本,*  杜大明, 王文廣,  王永梅.  吲哚類新主體化合物的固相光化學(xué)合成及包結(jié)性能研究[J].  高等學(xué)�；瘜W(xué)學(xué)報, 1994, 15(4), 528–531.
158.Ji-Ben Meng; Da-Ming Du, Guo-Xiang Xiong, Wen-Guang Wang, Yong-Mei Wang, H. Koshima, T. Matsuura*. A dual pathway in the solid-state photoreaction of nitrobenzaldehydes with Indole[J]. Journal of Heterocyclic Chemistry, 1994, 31(1),121–124.
159.Ji-Ben Meng,* Da-Ming Du, Yong-Mei Wang, Hong-Gen Wang, Ru-Ji Wang.
The synthesis and X-ray crystal structure studies of (di-3-indolyl)methylferrocene[J].
Chinese Journal of Structural Chemistry, 1993, 12(2), 85–88.
160.Ji-Ben Meng, Wen-Guang Wang, Guo-Xiang Xiong, Yong-Mei Wang, De-Chao
Fu, Da-Ming Du, Ru-Ji Wang, Hong-Gen Wang, H. Koshima, T. Matsuura*. A
multistep photoreaction of aromatic aldehydes with heteroaromatics in the solid
state[J]. Journal Photochemistry and Photobiology A: Chemistry, 1993, 74(1), 43–49.
161.Ji-Ben Meng,* Da-Ming Du, Yong-Mei Wang, Hong-Gen Wang, Ru-Ji Wang.
Solid state photochemical synthesis of a novel host compound methyl
4-(di-3-indolyl)-methylbenzoate and X-ray crystal structure of its 1:1 inclusion
complex with acetone[J]. Chinese Journal of Structural Chemistry, 1992, 11(5), 358–
361.
162.Ji-Ben Meng,* Da-Ming Du, Guo-Xiang Xiong, Wen-Guang Wang, Yong-Mei
Wang. The solid state controlled photochemical reaction of nitrobenzaldehydes
with indole[J]. Chinese Chemical Letters, 1992, 3(11), 865.
163.Ji-Ben Meng,* Da-Ming Du, Yong-Mei Wang, Ru-Ji Wang, Hong-Gen Wang.
The solid state controlled condensation reaction of ferrocenealdehyde and
indole[J]. Chinese Chemical Letters, 1992, 3(4), 247.
 
科研項目

1.方酰胺催化不對稱加成與串聯(lián)反應(yīng)合成雜環(huán)化合物研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
2.模塊組裝合成多齒手性配體及在不對稱催化反應(yīng)中的應(yīng)用研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
3.手性方酰胺催化不對稱串聯(lián)反應(yīng)合成含氮雜環(huán)化合物研究. (元素有機化學(xué)國家重點實驗室基金項目，項目負(fù)責(zé)人)
4.新型手性配體及催化劑設(shè)計合成與高效不對稱催化研究.?(北京理工大學(xué)科技創(chuàng)新計劃重大項目培育專項計劃,  項目負(fù)責(zé)人)
5.三齒手性配體的合成與不對稱催化反應(yīng)研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
6.新型 C3 對稱性手性配體的合成及其在不對稱催化反應(yīng)中的應(yīng)用. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
7.教育部新世紀(jì)優(yōu)秀人才支持計劃. (國家教育部人才項目，項目負(fù)責(zé)人)
8.有機合成化學(xué)與方法學(xué). (國家自然科學(xué)基金會創(chuàng)新群體項目，項目參加人)
9.新雜環(huán)手性配體的合成與不對稱催化反應(yīng)研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
10.新手性雙噁唑啉催化劑的設(shè)計合成與不對稱催化反應(yīng)研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
11.手性磷酰胺主體化合物的合成、分子識別及應(yīng)用基礎(chǔ)研究. (國家自然科學(xué)基金面上項目，項目負(fù)責(zé)人)
12.BG-1 原料藥合成實驗工藝的開發(fā)研究. (橫向項目，項目共同負(fù)責(zé)人)
13.新模板劑的合成. (橫向項目，項目負(fù)責(zé)人)
14.新型苯并環(huán)辛四烯超分子體系的設(shè)計合成和結(jié)構(gòu)鑒定. (留學(xué)歸國人員啟動基金項目，項目負(fù)責(zé)人)
15.手性磷酰胺主體的合成與分子識別. (中國博士后科學(xué)基金項目，項目負(fù)責(zé)人)
 
授權(quán)專利

1.Dimeric Compounds (Dimeric 5-amino-5,6,7,8-tetrahydroquinolinones and their
pharmaceutical use). United Kingdom Patent No: GB 2360518 A.
2.Dimeric Compounds (Dimeric 5-amino-5,6,7,8-tetrahydroquinolinones and their
pharmaceutical use). United States Patent No: US 6472408 B1.
3.一種簡便合成康普立停 A-4 前藥的方法. 中國專利號: ZL 02120895.6
4.手性二苯并[a,c]環(huán)庚二烯雙噁唑啉配體化合物及其制備與應(yīng)用.  中國專利號:ZL03101899.8
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